Knowles RG, Moncada S. Nitric oxide as a sign in blood vessels. Developments Biochem Sci. 1992;17(10):399–402.
Prast H, Philippu A. Nitric oxide as modulator of neuronal perform. Prog Neurobiol. 2001;64(1):51–68.
MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage perform. Annu Rev Immunol. 1997;15:323–50.
Mustafa AK, Gadalla MM, Snyder SH. Signaling by gasotransmitters. Sci Sign. 2009;2(68):2.
Szabo C. Gasotransmitters in most cancers: from pathophysiology to experimental remedy. Nat Rev Drug Discov. 2016;15(3):185–203.
Frances R, Munoz C, Zapater P, Uceda F, Gascon I, Pascual S, et al. Bacterial DNA prompts cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from sufferers with cirrhosis and ascites. Intestine. 2004;53(6):860–4.
McCafferty DM, Mudgett JS, Swain MG, Kubes P. Inducible nitric oxide synthase performs a vital function in resolving intestinal irritation. Gastroenterology. 1997;112(3):1022–7.
Panagaki T, Lozano-Montes L, Janickova L, Zuhra Okay, Szabo MP, Majtan T, et al. Overproduction of hydrogen sulfide, generated by cystathionine beta-synthase, disrupts mind wave patterns and contributes to neurobehavioral dysfunction in a rat mannequin of down syndrome. Redox Biol. 2022;51: 102233.
Shi Y, Pan F, Li H, Pan J, Qin S, Jiang D, et al. Carbon monoxide concentrations in paediatric sepsis syndrome. Arch Dis Baby. 2003;88(10):889–90.
Petros A, Bennett D, Vallance P. Impact of nitric oxide synthase inhibitors on hypotension in sufferers with septic shock. Lancet. 1991;338(8782–8783):1557–8.
Wang R. Gasotransmitters: rising pains and joys. Developments Biochem Sci. 2014;39(5):227–32.
Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, et al. Low-dose nitric oxide remedy for persistent pulmonary hypertension of the new child. Clin Inhaled Nitr Oxide Res Group. 2000. https://doi.org/10.1056/NEJM200002173420704.
Dominic P, Ahmad J, Bhandari R, Pardue S, Solorzano J, Jaisingh Okay, et al. Decreased availability of nitric oxide and hydrogen sulfide is a trademark of COVID-19. Redox Biol. 2021;43: 101982.
Signori D, Magliocca A, Hayashida Okay, Graw JA, Malhotra R, Bellani G, et al. Inhaled nitric oxide: function within the pathophysiology of cardio-cerebrovascular and respiratory illnesses. Intensive Care Med Exp. 2022;10(1):28.
Yu L, Hu P, Chen Y. Fuel-generating nanoplatforms: Materials chemistry, multifunctionality, and fuel remedy. Adv Mater. 2018;30(49): e1801964.
Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. International burden of 369 illnesses and accidents in 204 international locations and territories, 1990–2019: a scientific evaluation for the worldwide burden of illness examine 2019. Lancet. 2020;396(10258):1204–22.
Rabiei M, Kashanian S, Samavati SS, Derakhshankhah H, Jamasb S, McInnes SJP. Nanotechnology utility in drug supply to osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OSP). J Drug Supply Sci Technol. 2021;61: 102011.
Nichols SP, Storm WL, Koh A, Schoenfisch MH. Native supply of nitric oxide: focused supply of therapeutics to bone and connective tissues. Adv Drug Deliv Rev. 2012;64(12):1177–88.
Coneski PN, Schoenfisch MH. Nitric oxide launch: half III. Measure Report Chem Soc Rev. 2012;41(10):3753–8.
Gao L, Cheng J, Shen Z, Zhang G, Liu S, Hu J. Orchestrating nitric oxide and carbon monoxide signaling molecules for synergistic therapy of MRSA infections. Angew Chem Int Ed Engl. 2022;61(3): e202112782.
Su Z, Kong L, Dai Y, Tang J, Mei J, Qian Z, et al. Bioresponsive nano-antibacterials for H(2)S-sensitized hyperthermia and immunomodulation towards refractory implant-related infections. Sci Adv. 2022;8(14):eabn1701.
Ghafourifar P, Richter C. Nitric oxide synthase exercise in mitochondria. FEBS Lett. 1997;418(3):291–6.
Boggs S, Huang L, Stuehr DJ. Formation and reactions of the heme−dioxygen intermediate within the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy beneath single-turnover situations. Biochemistry. 2000;39(9):2332–9.
Palmer RM, Ferrige AG, Moncada S. Nitric oxide launch accounts for the organic exercise of endothelium-derived enjoyable issue. Nature. 1987;327(6122):524–6.
Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, et al. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically energetic compounds. Proc Natl Acad Sci USA. 1992;89(1):444–8.
Niedbala W, Wei XQ, Piedrafita D, Xu D, Liew FY. Results of nitric oxide on the induction and differentiation of Th1 cells. Eur J Immunol. 1999;29(8):2498–505.
Niedbala W, Wei XQ, Campbell C, Thomson D, Komai-Koma M, Liew FY. Nitric oxide preferentially induces sort 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression by way of cGMP. Proc Natl Acad Sci USA. 2002;99(25):16186–91.
Niedbala W, Besnard AG, Jiang HR, Alves-Filho JC, Fukada SY, Nascimento D, et al. Nitric oxide-induced regulatory T cells inhibit Th17 however not Th1 cell differentiation and performance. J Immunol. 2013;191(1):164–70.
Bogdan C. Regulation of lymphocytes by nitric oxide. In: Cuturi MC, Anegon I, editors. Suppression and Regulation of Immune Responses: Strategies and Protocols. Totowa: Humana Press; 2011. p. 375–93.
Cole C, Thomas S, Filak H, Henson PM, Lenz LL. Nitric oxide will increase susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity. 2012;36(5):807–20.
Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis will increase mouse osteoclast precursors with myeloid suppressor perform. J Clin Make investments. 2012;122(12):4592–605.
Bogdan C. Nitric oxide synthase in innate and adaptive immunity: an replace. Developments Immunol. 2015;36(3):161–78.
Ialenti A, Ianaro A, Moncada S, Di Rosa M. Modulation of acute irritation by endogenous nitric oxide. Eur J Pharmacol. 1992;211(2):177–82.
Weinberg JB, Granger DL, Pisetsky DS, Seldin MF, Misukonis MA, Mason SN, et al. The function of nitric oxide within the pathogenesis of spontaneous murine autoimmune illness: elevated nitric oxide manufacturing and nitric oxide synthase expression in MRL-lpr/lpr mice, and discount of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. J Exp Med. 1994;179(2):651–60.
Sasaki Okay, Hattori T, Fujisawa T, Takahashi Okay, Inoue H, Takigawa M. Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and fundamental fibroblast development consider cultured rabbit articular chondrocytes. J Biochem. 1998;123(3):431–9.
Ridnour LA, Windhausen AN, Isenberg JS, Yeung N, Thomas DD, Vitek MP, et al. Nitric oxide regulates matrix metalloproteinase-9 exercise by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci USA. 2007;104(43):16898–903.
Maneiro E, Lopez-Armada MJ, de Andres MC, Carames B, Martin MA, Bonilla A, et al. Impact of nitric oxide on mitochondrial respiratory exercise of human articular chondrocytes. Ann Rheum Dis. 2005;64(3):388–95.
Korhonen R, Lahti A, Kankaanranta H, Moilanen E. Nitric oxide manufacturing and signaling in irritation. Curr Drug Targets Inflamm Allergy. 2005;4(4):471–9.
Rosa SC, Judas F, Lopes MC, Mendes AF. Nitric oxide synthase isoforms and NF-κB exercise in regular and osteoarthritic human chondrocytes: regulation by inducible nitric oxide. Nitric Oxide. 2008;19(3):276–83.
Fabrino DL, Bleck CK, Anes E, Hasilik A, Melo RC, Niederweis M, et al. Porins facilitate nitric oxide-mediated killing of mycobacteria. Microbes Infect. 2009;11(10–11):868–75.
Jones-Carson J, Laughlin J, Hamad MA, Stewart AL, Voskuil MI, Vazquez-Torres A. Inactivation of [Fe-S] metalloproteins mediates nitric oxide-dependent killing of Burkholderia mallei. PLoS ONE. 2008;3(4): e1976.
Alican I, Kubes P. A vital function for nitric oxide in intestinal barrier perform and dysfunction. Am J Physiol. 1996;270(2 Pt 1):G225–37.
Richardson AR, Payne EC, Youthful N, Karlinsey JE, Thomas VC, Becker LA, et al. A number of targets of nitric oxide within the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium. Cell Host Microbe. 2011;10(1):33–43.
Lowik CW, Nibbering PH, van de Ruit M, Papapoulos SE. Inducible manufacturing of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is related to suppression of osteoclastic bone resorption. J Clin Make investments. 1994;93(4):1465–72.
Kasten TP, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Misko TP, et al. Potentiation of osteoclast bone-resorption exercise by inhibition of nitric oxide synthase. Proc Natl Acad Sci USA. 1994;91(9):3569–73.
Mancini L, Moradi-Bidhendi N, Becherini L, Martineti V, MacIntyre I. The biphasic results of nitric oxide in major rat osteoblasts are cGMP dependent. Biochem Biophys Res Commun. 2000;274(2):477–81.
van Hof RJ, Ralston SH. Cytokine-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast exercise. J Bone Miner Res. 1997;12(11):1797–804.
Wang PG, Xian M, Tang X, Wu X, Wen Z, Cai T, et al. Nitric oxide donors: chemical actions and organic functions. Chem Rev. 2002;102(4):1091–134.
Gong W, Xia C, He Q. Therapeutic fuel supply methods. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022;14(1): e1744.
Hu J, Whittaker MR, Duong H, Li Y, Boyer C, Davis TP. Biomimetic polymers aware of a organic signaling molecule: nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles. Angew Chem Int Ed Engl. 2014;53(30):7779–84.
Yang Y, Huang Z, Li LL. Superior nitric oxide donors: chemical construction of NO medication. Nanomed Biomed Appl Nanoscale. 2021;13(2):444–59.
Tan L, He C. Advances in inorganic-based colloidal nanovehicles functionalized for nitric oxide supply. Colloids Surf. 2021;199: 111508.
Li M, Aveyard J, Fleming G, Curran JM, McBride F, Raval R, et al. Nitric oxide releasing titanium surfaces for antimicrobial bone-integrating orthopedic implants. ACS Appl Mater Interfaces. 2020;12(20):22433–43.
Wu L, Cai X, Zhu H, Li J, Shi D, Su D, et al. PDT-driven extremely environment friendly intracellular supply and managed launch of CO together with adequate singlet oxygen manufacturing for synergistic anticancer remedy. Adv Funct Mater. 2018;28(41):1804324.
Chen Z, Zheng S, Shen Z, Cheng J, Xiao S, Zhang G, et al. Oxygen-tolerant photoredox catalysis triggers nitric oxide launch for antibacterial functions. Angew Chem Int Ed Engl. 2022;61(30): e202204526.
Wang J, Wang L, Pan J, Zhao J, Tang J, Jiang D, et al. Magneto-based synergetic remedy for implant-associated infections by way of biofilm disruption and innate immunity regulation. Adv Sci. 2021;8(6):2004010.
Ye J, Jiang J, Zhou Z, Weng Z, Xu Y, Liu L, et al. Close to-infrared mild and upconversion nanoparticle outlined ntric oxide-based osteoporosis focusing on remedy. ACS Nano. 2021;15(8):13692–702.
Chen X, Liu Y, Wen Y, Yu Q, Liu J, Zhao Y, et al. A photothermal-triggered nitric oxide nanogenerator mixed with siRNA for exact remedy of osteoarthritis by suppressing macrophage irritation. Nanoscale. 2019;11(14):6693–709.
Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, et al. Low-grade irritation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(10):580–92.
Taskiran D, Stefanovic-Racic M, Georgescu H, Evans C. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun. 1994;200(1):142–8.
Ostojic M, Zevrnja A, Vukojevic Okay, Soljic V. Immunofluorescence evaluation of NF-kB and iNOS expression in several cell populations throughout early and superior knee osteoarthritis. Int J Mol Sci. 2021;22(12):6461.
Xu J, Chi F, Guo T, Punj V, Lee WN, French SW, et al. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Make investments. 2015;125(4):1579–90.
Neurath MF, Pettersson S, Meyer Zum Büschenfelde Okay-H, Strober W. Native administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice. Nat Med. 1996;2(9):998–1004.
O’Neill LA, Hardie DG. Metabolism of irritation restricted by AMPK and pseudo-starvation. Nature. 2013;493(7432):346–55.
Jin P, Wiraja C, Zhao J, Zhang J, Zheng L, Xu C. nitric oxide nanosensors for predicting the event of osteoarthritis in rat mannequin. ACS Appl Mater Inter. 2017;9(30):25128–37.
Zhang X, Kim WS, Hatcher N, Potgieter Okay, Moroz LL, Gillette R, et al. Interfering with nitric oxide measurements 4,5-diaminofluorescein reacts with dehydroascorbic acid and ascorbic acid. J Biol Chem. 2002;277(50):48472–8.
Kojima H, Nagano T. Fluorescent indicators for nitric oxide. Adv Mater. 2000;12(10):763–5.
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205–19.
McInnes IB, Leung BP, Subject M, Wei XQ, Huang FP, Sturrock RD, et al. Manufacturing of nitric oxide within the synovial membrane of rheumatoid and osteoarthritis sufferers. J Exp Med. 1996;184(4):1519–24.
Choi JW. Nitric oxide manufacturing is elevated in sufferers with rheumatoid arthritis however doesn’t correlate with laboratory parameters of illness exercise. Clin Chim Acta. 2003;336(1–2):83–7.
Ueki Y, Miyake S, Tominaga Y, Eguchi Okay. Elevated nitric oxide ranges in sufferers with rheumatoid arthritis. J Rheumatol. 1996;23(2):230–6.
Farrell AJ, Blake DR, Palmer RM, Moncada S. Elevated concentrations of nitrite in synovial fluid and serum samples counsel elevated nitric oxide synthesis in rheumatic illnesses. Ann Rheum Dis. 1992;51(11):1219–22.
St Clair EW, Wilkinson WE, Lang T, Sanders L, Misukonis MA, Gilkeson GS, et al. Elevated expression of blood mononuclear cell nitric oxide synthase sort 2 in rheumatoid arthritis sufferers. J Exp Med. 1996;184(3):1173–8.
van Hof RJ, Hocking L, Wright PK, Ralston SH. Nitric oxide is a mediator of apoptosis within the rheumatoid joint. Rheumatology. 2000;39(9):1004–8.
Yeo J, Lee YM, Lee J, Park D, Kim Okay, Kim J, et al. Nitric oxide-scavenging nanogel for treating rheumatoid arthritis. Nano Lett. 2019;19(10):6716–24.
Chakraborty S, Balakotaiah V, Bidani A. 2004 Diffusing capability reexamined: relative roles of diffusion and chemical response in crimson cell uptake of O2, CO, CO2, and NO. J Appl Physiol. 1985;97(6):2284–302.
Lancaster JR Jr, Gaston B. NO and nitrosothiols: spatial confinement and free diffusion. Am J Physiol Lung Cell Mol Physiol. 2004;287(3):L465–6.
Kim T, Suh J, Kim WJ. Polymeric aggregate-embodied hybrid nitric-oxide-scavenging and sequential drug-releasing hydrogel for combinatorial therapy of rheumatoid arthritis. Adv Mater. 2021;33(34): e2008793.
Webber MJ, Pashuck ET. (Macro)molecular self-assembly for hydrogel drug supply. Adv Drug Deliv Rev. 2021;172:275–95.
Staurengo-Ferrari L, Mizokami SS, Silva JJ, da Silva FO, Sousa EH, da Franca LG, et al. The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory ache: involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol Biochem Behav. 2013;105:157–65.
Rossaneis AC, Longhi-Balbinot DT, Bertozzi MM, Fattori V, Segato-Vendrameto CZ, Badaro-Garcia S, et al. [Ru(bpy)(2)(NO)SO(3)](PF(6)), a Nitric oxide donating ruthenium advanced, reduces gout arthritis in mice. Entrance Pharmacol. 2019;10:229.
Li F, Collins JG, Keene FR. Ruthenium complexes as antimicrobial brokers. Chem Soc Rev. 2015;44(8):2529–42.
Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the longer term. Lancet. 2011;377(9773):1276–87.
Datta HK, Ng WF, Walker JA, Tuck SP, Varanasi SS. The cell biology of bone metabolism. J Clin Pathol. 2008;61(5):577–87.
Lufkin EG, Wahner HW, O’Fallon WM, Hodgson SF, Kotowicz MA, Lane AW, et al. Therapy of postmenopausal osteoporosis with transdermal estrogen. Ann Intern Med. 1992;117(1):1–9.
Bartl R, Frisch B. Osteoporosis: analysis, prevention, remedy. Berlin: Springer Science Enterprise Media; 2009.
Riggs BL, Khosla S, Melton LJ third. A unitary mannequin for involutional osteoporosis: estrogen deficiency causes each sort I and sort II osteoporosis in postmenopausal girls and contributes to bone loss in ageing males. J Bone Miner Res. 1998;13(5):763–73.
Manolagas SC. From estrogen-centric to ageing and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010;31(3):266–300.
Ozgocmen S, Kaya H, Fadillioglu E, Aydogan R, Yilmaz Z. Position of antioxidant methods, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol Cell Biochem. 2007;295(1–2):45–52.
Sendur OF, Turan Y, Tastaban E, Serter M. Antioxidant standing in sufferers with osteoporosis: a managed examine. Joint Bone Backbone. 2009;76(5):514–8.
Stacey E, Korkia P, Hukkanen MV, Polak JM, Rutherford OM. Decreased nitric oxide ranges and bone turnover in amenorrheic athletes with spinal osteopenia. J Clin Endocrinol Metab. 1998;83(9):3056–61.
Wimalawansa SJ. Rationale for utilizing nitric oxide donor remedy for prevention of bone loss and therapy of osteoporosis in people. Ann NY Acad Sci. 2007;1117(1):283–97.
Wimalawansa SJ. Nitroglycerin remedy is as efficacious as customary estrogen substitute remedy (Premarin) in prevention of oophorectomy-induced bone loss: a human pilot scientific examine. J Bone Miner Res. 2000;15(11):2240–4.
Jeddi S, Yousefzadeh N, Kashfi Okay, Ghasemi A. Position of nitric oxide in sort 1 diabetes-induced osteoporosis. Biochem Pharmacol. 2022;197: 114888.
Deodhar AA, Woolf AD. Bone mass measurement and bone metabolism in rheumatoid arthritis: a assessment. Br J Rheumatol. 1996;35(4):309–22.
Will R, Palmer R, Bhalla AK, Ring F, Calin A. Osteoporosis in early ankylosing spondylitis: a major pathological occasion? Lancet. 1989;2(8678–8679):1483–5.
Armour KE, Van THRJ, Grabowski PS, Reid DM, Ralston SH. Proof for a pathogenic function of nitric oxide in inflammation-induced osteoporosis. J Bone Miner Res. 1999;14(12):2137–42.
Poole KE, Compston JE. Osteoporosis and its administration. BMJ. 2006;333(7581):1251–6.
Ott SM. Lengthy-term security of bisphosphonates. J Clin Endocrinol Metab. 2005;90(3):1897–9.
Gow AJ, Stamler JS. Reactions between nitric oxide and haemoglobin beneath physiological situations. Nature. 1998;391(6663):169–73.
Lin YJ, Chen CC, Chi NW, Nguyen T, Lu HY, Nguyen D, et al. In situ self-assembling micellar depots that may actively lure and passively launch NO with long-lasting exercise to reverse osteoporosis. Adv Mater. 2018;30(22): e1705605.
Reid IR. Brief-term and long-term results of osteoporosis therapies. Nat Rev Endocrinol. 2015;11(7):418–28.
Docheva D, Muller SA, Majewski M, Evans CH. Biologics for tendon restore. Adv Drug Deliv Rev. 2015;84:222–39.
Sheng D, Li J, Ai C, Feng S, Ying T, Liu X, et al. Electrospun PCL/Gel-aligned scaffolds improve the biomechanical energy in tendon restore. J Mater Chem B. 2019;7(31):4801–10.
Nourissat G, Berenbaum F, Duprez D. Tendon harm: from biology to tendon restore. Nat Rev Rheumatol. 2015;11(4):223–33.
Harrison DG, Widder J, Grumbach I, Chen W, Weber M, Searles C. Endothelial mechanotransduction, nitric oxide and vascular irritation. J Intern Med. 2006;259(4):351–63.
Arciola CR, Campoccia D, Montanaro L. Implant infections: adhesion, biofilm formation and immune evasion. Nat Rev Microbiol. 2018;16(7):397–409.
Gilchrist RK, Medal R, Shorey WD, Hanselman RC, Parrott JC, Taylor CB. Selective inductive heating of lymph nodes. Ann Surg. 1957;146(4):596–606.
Schwarz P, Diem R, Dun NJ, Forstermann U. Endogenous and exogenous nitric oxide inhibits norepinephrine launch from rat coronary heart sympathetic nerves. Circ Res. 1995;77(4):841–8.
Nakano A, Liu GS, Heusch G, Downey JM, Cohen MV. Exogenous nitric oxide can set off a preconditioned state by a free radical mechanism, however endogenous nitric oxide is just not a set off of classical ischemic preconditioning. J Mol Cell Cardiol. 2000;32(7):1159–67.
Peralta C, Rull R, Rimola A, Deulofeu R, Roselló-Catafau J, Gelpí E, et al. Endogenous nitric oxide and exogenous nitric oxide supplementation in hepatic ischemia-reperfusion harm within the Rat1. Transplantation. 2001;71(4):529–36.
Mitsutomi N, Akashi C, Odagiri J, Matsumura Y. Results of endogenous and exogenous nitric oxide on endothelin-1 manufacturing in cultured vascular endothelial cells. Eur J Pharmacol. 1999;364(1):65–73.
Eigler A, Moeller J, Endres S. Exogenous and endogenous nitric oxide attenuates tumor necrosis issue synthesis within the murine macrophage cell line uncooked 2647. J Immunol. 1995;154(8):4048–54.
Ahern GP, Hsu SF, Klyachko VA, Jackson MB. Induction of persistent sodium present by exogenous and endogenous nitric oxide. J Biol Chem. 2000;275(37):28810–5.
Searcy DG, Lee SH. Sulfur discount by human erythrocytes. J Exp Zool. 1998;282(3):310–22.
Mustafa AK, Sikka G, Gazi SK, Steppan J, Jung SM, Bhunia AK, et al. Hydrogen sulfide as endothelium-derived hyperpolarizing issue sulfhydrates potassium channels. Circ Res. 2011;109(11):1259–68.
Mustafa AK, Gadalla MM, Sen N, Kim S, Mu W, Gazi SK, et al. H2S alerts by protein S-sulfhydration. Sci Sign. 2009;2(96):ra72.
Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, et al. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl Acad Sci USA. 2009;106(51):21972–7.
Yang G, Wu L, Bryan S, Khaper N, Mani S, Wang R. Cystathionine gamma-lyase deficiency and overproliferation of easy muscle cells. Cardiovasc Res. 2010;86(3):487–95.
Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion harm by preservation of mitochondrial perform. Proc Natl Acad Sci USA. 2007;104(39):15560–5.
Lv B, Chen S, Tang C, Jin H, Du J, Huang Y. Hydrogen sulfide and vascular regulation—an replace. J Adv Res. 2021;27:85–97.
Dilek N, Papapetropoulos A, Toliver-Kinsky T, Szabo C. Hydrogen sulfide: an endogenous regulator of the immune system. Pharmacol Res. 2020;161: 105119.
Zanardo RC, Brancaleone V, Distrutti E, Fiorucci S, Cirino G, Wallace JL. Hydrogen sulfide is an endogenous modulator of leukocyte-mediated irritation. FASEB J. 2006;20(12):2118–20.
Oh GS, Pae HO, Lee BS, Kim BN, Kim JM, Kim HR, et al. Hydrogen sulfide inhibits nitric oxide manufacturing and nuclear factor-κB by way of heme oxygenase-1 expression in RAW2647 macrophages stimulated with lipopolysaccharide. Free Radic Biol Med. 2006;41(1):106–19.
Yang R, Qu C, Zhou Y, Konkel JE, Shi S, Liu Y, et al. Hydrogen sulfide promotes Tet1- and Tet2-mediated Foxp3 demethylation to drive regulatory T cell differentiation and preserve immune homeostasis. Immunity. 2015;43(2):251–63.
Cooper CE, Brown GC. The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J Bioenerg Biomembr. 2008;40(5):533–9.
Wallace JL, Wang R. Hydrogen sulfide-based therapeutics: exploiting a novel however ubiquitous gasotransmitter. Nat Rev Drug Discov. 2015;14(5):329–45.
Buret AG, Allain T, Motta JP, Wallace JL. Results of hydrogen sulfide on the microbiome: from toxicity to remedy. Antioxid Redox Sign. 2022;36(4–6):211–9.
Liu Y, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, et al. Hydrogen sulfide maintains mesenchymal stem cell perform and bone homeostasis by way of regulation of Ca(2+) channel sulfhydration. Cell Stem Cell. 2014;15(1):66–78.
Zheng Y, Liao F, Lin X, Zheng F, Fan J, Cui Q, et al. Cystathionine γ-lyase-hydrogen sulfide induces runt-related transcription issue 2 sulfhydration, thereby growing osteoblast exercise to advertise bone fracture therapeutic. Antioxid Redox Sign. 2017;27(11):742–53.
Gambari L, Lisignoli G, Cattini L, Manferdini C, Facchini A, Grassi F. Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells by way of NRF2-dependent mechanism. Pharmacol Res. 2014;87:99–112.
Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, et al. Cystathionine γ-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic evaluation. Arterioscler Thromb Vasc Biol. 2014;34(3):626–34.
Grassi F, Tyagi AM, Calvert JW, Gambari L, Walker LD, Yu M, et al. Hydrogen sulfide is a novel regulator of bone formation implicated within the bone loss induced by estrogen deficiency. J Bone Miner Res. 2016;31(5):949–63.
Xu ZS, Wang XY, Xiao DM, Hu LF, Lu M, Wu ZY, et al. Hydrogen sulfide protects MC3T3-E1 osteoblastic cells towards H2O2-induced oxidative damage-implications for the therapy of osteoporosis. Free Radic Biol Med. 2011;50(10):1314–23.
Zhai Y, Behera J, Tyagi SC, Tyagi N. Hydrogen sulfide attenuates homocysteine-induced osteoblast dysfunction by inhibiting mitochondrial toxicity. J Cell Physiol. 2019;234(10):18602–14.
Xu D, Jin H, Wen J, Chen J, Chen D, Cai N, et al. Hydrogen sulfide protects towards endoplasmic reticulum stress and mitochondrial harm in nucleus pulposus cells and ameliorates intervertebral disc degeneration. Pharmacol Res. 2017;117:357–69.
Yu Y, Wang Z, Ding Q, Yu X, Yang Q, Wang R, et al. The Preparation of a novel poly(Lactic Acid)-based sustained h(2)s releasing microsphere for rheumatoid arthritis alleviation. Pharmaceutics. 2021;13(5):742.
Yu Y, Wang Z, Yang Q, Ding Q, Wang R, Li Z, et al. A novel dendritic mesoporous silica primarily based sustained hydrogen sulfide donor for the alleviation of adjuvant-induced irritation in rats. Drug Deliv. 2021;28(1):1031–42.
Wu WJ, Jia WW, Liu XH, Pan LL, Zhang QY, Yang D, et al. S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway. Redox Biol. 2016;10:157–67.
Chen Z, Chen G, Lin W, Li J, Fang L, Wang X, et al. Sign-on and extremely delicate electrochemiluminescence biosensor for hydrogen sulfide in joint fluid primarily based on silver-ion-mediated base pairs and hybridization chain response. Chemosensors. 2022;10(7):250.
Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG. Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis sufferers: relation to scientific and laboratory measures of irritation. Ann NY Acad Sci. 2010;1203(1):146–50.
Kang J, Li Z, Organ CL, Park CM, Yang CT, Pacheco A, et al. pH-controlled hydrogen sulfide launch for myocardial ischemia-reperfusion harm. J Am Chem Soc. 2016;138(20):6336–9.
Zheng Z, Chen A, He H, Chen Y, Chen J, Albashari AA, et al. pH and enzyme dual-responsive launch of hydrogen sulfide for disc degeneration remedy. J Mater Chem B. 2019;7(4):611–8.
Batallé G, Cabarga L, Pol O. The inhibitory results of slow-releasing hydrogen sulfide donors within the mechanical allodynia, grip energy deficits, and depressive-like behaviors related to continual osteoarthritis ache. Antioxidants. 2020;9(1):31.
Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from fundamental science to therapeutic functions. Physiol Rev. 2006;86(2):583–650.
Poss KD, Tonegawa S. Diminished stress protection in heme oxygenase 1-deficient cells. Proc Natl Acad Sci U S A. 1997;94(20):10925–30.
Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, et al. Carbon monoxide poisoning: pathogenesis, administration, and future instructions of remedy. Am J Respir Crit Care Med. 2017;195(5):596–606.
Kharitonov VG, Sharma VS, Pilz RB, Magde D, Koesling D. Foundation of guanylate cyclase activation by carbon monoxide. Proc Natl Acad Sci USA. 1995;92(7):2568–71.
Morita T, Perrella MA, Lee ME, Kourembanas S. Clean muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci USA. 1995;92(5):1475–9.
Ma X, Sayed N, Beuve A, van den Akker F. NO and CO differentially activate soluble guanylyl cyclase by way of a heme pivot-bend mechanism. EMBO J. 2007;26(2):578–88.
Martin E, Berka V, Bogatenkova E, Murad F, Tsai AL. Ligand selectivity of soluble guanylyl cyclase: impact of the hydrogen-bonding tyrosine within the distal heme pocket on binding of oxygen, nitric oxide, and carbon monoxide. J Biol Chem. 2006;281(38):27836–45.
Marazioti A, Bucci M, Coletta C, Vellecco V, Baskaran P, Szabo C, et al. Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules. Arterioscler Thromb Vasc Biol. 2011;31(11):2570–6.
Kajimura M, Shimoyama M, Tsuyama S, Suzuki T, Kozaki S, Takenaka S, et al. Visualization of gaseous monoxide reception by soluble guanylate cyclase within the rat retina. FASEB J. 2003;17(3):506–8.
Lu W, Yang X, Wang B. Carbon monoxide signaling and soluble guanylyl cyclase: Info, myths, and intriguing potentialities. Biochem Pharmacol. 2022;200: 115041.
Tetreau C, Tourbez M, Gorren A, Mayer B, Lavalette D. Dynamics of carbon monoxide binding with neuronal nitric oxide synthase. Biochemistry. 1999;38(22):7210–8.
White KA, Marletta MA. Nitric oxide synthase is a cytochrome P-450 sort hemoprotein. Biochemistry. 1992;31(29):6627–31.
Yang PM, Huang YT, Zhang YQ, Hsieh CW, Wung BS. Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation by a calcium and phosphatidylinositol 3-kinase/Akt mechanism. Vascul Pharmacol. 2016;87:209–18.
Liu XM, Peyton KJ, Ensenat D, Wang H, Hannink M, Alam J, et al. Nitric oxide stimulates heme oxygenase-1 gene transcription by way of the Nrf2/ARE advanced to advertise vascular easy muscle cell survival. Cardiovasc Res. 2007;75(2):381–9.
Fernandes DG, Nunes J, Tomé CS, Zuhra Okay, Costa JM, Antunes AM, et al. Human cystathionine γ-lyase is inhibited by S-nitrosation: a brand new crosstalk mechanism between NO and H2S. Antioxidants. 2021;10(9):1391.
Kram L, Grambow E, Mueller-Graf F, Sorg H, Vollmar B. The anti-thrombotic impact of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthases. Thromb Res. 2013;132(2):e112–7.
Jia L, Wang Y, Wang Y, Ma Y, Shen J, Fu Z, et al. Heme oxygenase-1 in macrophages drives septic cardiac dysfunction by way of suppressing lysosomal degradation of inducible nitric oxide synthase. Circ Res. 2018;122(11):1532–44.
Batallé G, Bai X, Pol O. The interplay between carbon monoxide and hydrogen sulfide throughout continual joint ache in younger feminine mice. Antioxidants. 2022;11(7):1271.
Sen N, Paul BD, Gadalla MM, Mustafa AK, Sen T, Xu R, et al. Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell. 2012;45(1):13–24.
Onyiah JC, Sheikh SZ, Maharshak N, Steinbach EC, Russo SM, Kobayashi T, et al. Carbon monoxide and heme oxygenase-1 stop intestinal irritation in mice by selling bacterial clearance. Gastroenterology. 2013;144(4):789–98.
Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, et al. Macrophages sense and kill micro organism by carbon monoxide-dependent inflammasome activation. J Clin Make investments. 2014;124(11):4926–40.
Jung SS, Moon JS, Xu JF, Ifedigbo E, Ryter SW, Choi AM, et al. Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages. Am J Physiol Lung Cell Mol Physiol. 2015;308(10):L1058–67.
Bilban M, Bach FH, Otterbein SL, Ifedigbo E, d’Avila JC, Esterbauer H, et al. Carbon monoxide orchestrates a protecting response by PPARγ. Immunity. 2006;24(5):601–10.
Otterbein LE, Bach FH, Alam J, Soares M, Tao LuH, Wysk M, et al. Carbon monoxide has anti-inflammatory results involving the mitogen-activated protein kinase pathway. Nat Med. 2000;6(4):422–8.
Jamal Uddin M, Joe Y, Kim SK, Oh Jeong S, Ryter SW, Pae HO, et al. IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine manufacturing. Cell Mol Immunol. 2016;13(2):170–9.
Bathoorn E, Slebos DJ, Postma DS, Koeter GH, van Oosterhout AJ, van der Toorn M, et al. Anti-inflammatory results of inhaled carbon monoxide in sufferers with COPD: a pilot examine. Eur Respir J. 2007;30(6):1131–7.
Wang SB, Zhang C, Chen ZX, Ye JJ, Peng SY, Rong L, et al. A flexible carbon monoxide nanogenerator for enhanced tumor remedy and anti-Irritation. ACS Nano. 2019;13(5):5523–32.
Cheng J, Hu J. Latest advances on carbon monoxide releasing molecules for antibacterial functions. ChemMedChem. 2021;16(24):3628–34.
Wareham LK, Begg R, Jesse HE, Van Beilen JW, Ali S, Svistunenko D, et al. Carbon monoxide fuel is just not inert, however world, in its penalties for bacterial gene expression, iron acquisition, and antibiotic resistance. Antioxid Redox Sign. 2016;24(17):1013–28.
Bak SU, Kim S, Hwang HJ, Yun JA, Kim WS, Received MH, et al. Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation. BMB Rep. 2017;50(2):103–8.
Li J, Tune L, Hou M, Wang P, Wei L, Tune H. Carbon monoxide releasing molecule-3 promotes the osteogenic differentiation of rat bone marrow mesenchymal stem cells by releasing carbon monoxide. Int J Mol Med. 2018;41(4):2297–305.
Kobayashi H, Takeno M, Saito T, Takeda Y, Kirino Y, Noyori Okay, et al. Regulatory function of heme oxygenase 1 in irritation of rheumatoid arthritis. Arthritis Rheum. 2006;54(4):1132–42.
Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, et al. Hyaluronan receptor LYVE-1-expressing macrophages preserve arterial tone by hyaluronan-mediated regulation of easy muscle cell collagen. Immunity. 2018;49(2):326–41.
Kraus VB, McDaniel G, Huebner JL, Stabler TV, Pieper CF, Shipes SW, et al. Direct in vivo proof of activated macrophages in human osteoarthritis. Osteoarthritis Cartilage. 2016;24(9):1613–21.
Yang G, Fan M, Zhu J, Ling C, Wu L, Zhang X, et al. A multifunctional anti-inflammatory drug that may particularly goal activated macrophages, massively deplete intracellular H(2)O(2), and produce massive quantities CO for a extremely environment friendly therapy of osteoarthritis. Biomaterials. 2020;255: 120155.
Yuan Z, Wu J, Fu Z, Meng S, Dai L, Cai Okay. Polydopamine-mediated interfacial functionalization of implants for accelerating contaminated bone restore by light-activatable antibiosis and carbon monoxide fuel regulated macrophage polarization. Adv Funct Mater. 2022;32(27):2200374.
Musser JM, Schlievert PM, Chow AW, Ewan P, Kreiswirth BN, Rosdahl VT, et al. A single clone of Staphylococcus aureus causes nearly all of instances of poisonous shock syndrome. Proc Natl Acad Sci U S A. 1990;87(1):225–9.
Cheng J, Gan G, Shen Z, Gao L, Zhang G, Hu J. Purple light-triggered intracellular carbon monoxide launch permits selective eradication of MRSA an infection. Angew Chem Int Ed Engl. 2021;60(24):13513–20.
Liu X, Miller MJS, Joshi MS, Sadowska-Krowicka H, Clark DA, Lancaster JR Jr. Diffusion-limited response of free nitric oxide with erythrocytes *. J Biol Chem. 1998;273(30):18709–13.
Thomas DD, Liu X, Kantrow SP, Lancaster JR Jr. The organic lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci USA. 2001;98(1):355–60.
Whitfield NL, Kreimier EL, Verdial FC, Skovgaard N, Olson KR. Reappraisal of H2S/sulfide focus in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling. Am J Physiol Regul Integr Comp Physiol. 2008;294(6):R1930–7.
Vitvitsky V, Kabil O, Banerjee R. Excessive turnover charges for hydrogen sulfide permit for fast regulation of its tissue concentrations. Antioxid Redox Sign. 2012;17(1):22–31.
Buboltz JB, Robins M. Hyperbaric therapy of carbon monoxide toxicity. Tampa: StatPearls Publishing; 2022.
Piantadosi CA. Organic chemistry of carbon monoxide. Antioxid Redox Sign. 2002;4(2):259–70.
Corridor CN, Garthwaite J. What’s the actual physiological NO focus in vivo? Nitric Oxide. 2009;21(2):92–103.
Lee Y, Kim J. Simultaneous electrochemical detection of nitric oxide and carbon monoxide generated from mouse kidney organ tissues. Anal Chem. 2007;79(20):7669–75.
Abe Okay, Kimura H. The doable function of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16(3):1066–71.
Amin AR, Di Cesare PE, Vyas P, Attur M, Tzeng E, Billiar TR, et al. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: proof for up-regulated neuronal nitric oxide synthase. J Exp Med. 1995;182(6):2097–102.
Clancy RM, Gomez PF, Abramson SB. Nitric oxide sustains nuclear issue kappaB activation in cytokine-stimulated chondrocytes. Osteoarthr Cartil. 2004;12(7):552–8.
Nagy G, Clark JM, Buzas E, Gorman C, Pasztoi M, Koncz A, et al. Nitric oxide manufacturing of T lymphocytes is elevated in rheumatoid arthritis. Immunol Lett. 2008;118(1):55–8.
Grabowski PS, Wright PK, Van Hof RJ, Helfrich MH, Ohshima H, Ralston SH. Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis. Br J Rheumatol. 1997;36(6):651–5.
van Hof RJ, Armour KJ, Smith LM, Armour KE, Wei XQ, Liew FY, et al. Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption. Proc Natl Acad Sci U S A. 2000;97(14):7993–8.
Sterck JG, Klein-Nulend J, Lips P, Burger EH. Response of regular and osteoporotic human bone cells to mechanical stress in vitro. Am J Physiol. 1998;274(6):E1113–20.
Armour KJ, Armour KE, van Hof RJ, Reid DM, Wei XQ, Liew FY, et al. Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and inflicting osteoblast apoptosis. Arthr Rheum. 2001;44(12):2790–6.
Wang J, Kalhor A, Lu S, Crawford R, Ni JD, Xiao Y. iNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis. Acta Orthop. 2015;86(1):134–41.
Zhao X, Yang F, Solar L, Zhang A. Affiliation between NOS3 polymorphisms and osteonecrosis of the femoral head. Artif Cells Nanomed Biotechnol. 2019;47(1):1423–7.
Furusawa N, Baba H, Miyoshi N, Maezawa Y, Uchida Okay, Kokubo Y, et al. Herniation of cervical intervertebral disc: immunohistochemical examination and measurement of nitric oxide manufacturing. Backbone. 2001;26(10):1110–6.
Kang JD, Stefanovic-Racic M, McIntyre LA, Georgescu HI, Evans CH. Towards a biochemical understanding of human intervertebral disc degeneration and herniation contributions of nitric oxide, interleukins, prostaglandin E2 and matrix metalloproteinases. Backbone. 1997;22(10):1065–73.
Ersoy Y, Ozerol E, Baysal O, Temel I, MacWalter RS, Meral U, et al. Serum nitrate and nitrite ranges in sufferers with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Ann Rheum Dis. 2002;61(1):76–8.
Kozaci LD, Sari I, Alacacioglu A, Akar S, Akkoc N. Analysis of irritation and oxidative stress in ankylosing spondylitis: a task for macrophage migration inhibitory issue. Mod Rheumatol. 2010;20(1):34–9.
Ozgocmen S, Sogut S, Ardicoglu O, Fadillioglu E, Pekkutucu I, Akyol O. Serum nitric oxide, catalase, superoxide dismutase, and malondialdehyde standing in sufferers with ankylosing spondylitis. Rheumatol Int. 2004;24(2):80–3.
Liu R, Liote F, Rose DM, Merz D, Terkeltaub R. Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide manufacturing and matrix metalloproteinase 3 expression in chondrocytes. Arthritis Rheum. 2004;50(1):247–58.
Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67(5):1739–42.
Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide manufacturing of human vascular cells. J Am Soc Nephrol. 2005;16(12):3553–62.
Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, et al. Elevated uric acid will increase blood stress within the rat by a novel crystal-independent mechanism. Hypertension. 2001;38(5):1101–6.