Nanotechnology

Machine-learning-assisted single-vessel evaluation of nanoparticle permeability in tumour vasculatures

Machine-learning-assisted single-vessel evaluation of nanoparticle permeability in tumour vasculatures
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  • Jain, R. Ok. & Stylianopoulos, T. Delivering nanomedicine to stable tumors. Nat. Rev. Clin. Oncol. 7, 653–664 (2010).

    Article 
    CAS 

    Google Scholar
     

  • Blanco, E., Shen, H. & Ferrari, M. Rules of nanoparticle design for overcoming organic obstacles to drug supply. Nat. Biotechnol. 33, 941–951 (2015).

    Article 
    CAS 

    Google Scholar
     

  • Huang, X. et al. Hypoxia-tropic protein nanocages for modulation of tumor- and chemotherapy-associated hypoxia. ACS Nano 13, 236–247 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Dvorak, A. M. et al. The vesiculo-vacuolar organelle (VVO): a definite endothelial cell construction that gives a transcellular pathway for macromolecular extravasation. J. Leukoc. Biol. 59, 100–115 (1996).

    Article 
    CAS 

    Google Scholar
     

  • Dvorak, A. M. & Feng, D. The vesiculo-vacuolar organelle (VVO). A brand new endothelial cell permeability organelle. J. Histochem. Cytochem. 49, 419–432 (2001).

    Article 
    CAS 

    Google Scholar
     

  • Claesson-Welsh, L. Vascular permeability—the necessities. Ups. J. Med Sci. 120, 135–143 (2015).

    Article 

    Google Scholar
     

  • Matsumura, Y. & Maeda, H. A brand new idea for macromolecular therapeutics in most cancers chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Most cancers Res. 46, 6387–6392 (1986).

    CAS 

    Google Scholar
     

  • Sindhwani, S. et al. The entry of nanoparticles into stable tumours. Nat. Mater. 19, 566–575 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Butler, Ok. T., Davies, D. W., Cartwright, H., Isayev, O. & Walsh, A. Machine studying for molecular and supplies science. Nature 559, 547–555 (2018).

    Article 
    CAS 

    Google Scholar
     

  • Moen, E. et al. Deep studying for mobile picture evaluation. Nat. Strategies 16, 1233–1246 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Greenwald, N. F. et al. Complete-cell segmentation of tissue photographs with human-level efficiency utilizing large-scale information annotation and deep studying. Nat. Biotechnol. 40, 555–565 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Wei, Y. et al. Prediction and design of nanozymes utilizing explainable machine studying. Adv. Mater. 34, e2201736 (2022).

    Article 

    Google Scholar
     

  • Lin, X. et al. Chimeric ferritin nanocages for a number of perform loading and multimodal imaging. Nano Lett. 11, 814–819 (2011).

    Article 
    CAS 

    Google Scholar
     

  • Fan, Ok. et al. Magnetoferritin nanoparticles for concentrating on and visualizing tumour tissues. Nat. Nanotechnol. 7, 459–464 (2012).

    Article 
    CAS 

    Google Scholar
     

  • Litjens, G. et al. A survey on deep studying in medical picture evaluation. Med. Picture Anal. 42, 60–88 (2017).

    Article 

    Google Scholar
     

  • Caicedo, J. C. et al. Information-analysis methods for image-based cell profiling. Nat. Strategies 14, 849–863 (2017).

    Article 
    CAS 

    Google Scholar
     

  • Falk, T. et al. U-Web: deep studying for cell counting, detection, and morphometry. Nat. Strategies 16, 67–70 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Todorov, M. I. et al. Machine studying evaluation of entire mouse mind vasculature. Nat. Strategies 17, 442–449 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Zhang, Y. et al. Biomimetic design of mitochondria-targeted hybrid nanozymes as superoxide scavengers. Adv. Mater. 33, e2006570 (2021).

    Article 

    Google Scholar
     

  • Nagy, J. A., Chang, S. H., Shih, S. C., Dvorak, A. M. & Dvorak, H. F. Heterogeneity of the tumor vasculature. Semin Thromb. Hemost. 36, 321–331 (2010).

    Article 
    CAS 

    Google Scholar
     

  • Feng, D., Nagy, J. A., Dvorak, A. M. & Dvorak, H. F. Totally different pathways of macromolecule extravasation from hyperpermeable tumor vessels. Microvasc. Res. 59, 24–37 (2000).

    Article 
    CAS 

    Google Scholar
     

  • Bonam, S. R., Wang, F. & Muller, S. Lysosomes as a therapeutic goal. Nat. Rev. Drug Discov. 18, 923–948 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Rennick, J. J., Johnston, A. P. R. & Parton, R. G. Key ideas and strategies for learning the endocytosis of organic and nanoparticle therapeutics. Nat. Nanotechnol. 16, 266–276 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Tai, W., Li, J., Corey, E. & Gao, X. A ribonucleoprotein octamer for focused siRNA supply. Nat. Biomed. Eng. 2, 326–337 (2018).

    Article 
    CAS 

    Google Scholar
     

  • Bern, M. et al. An engineered human albumin enhances half-life and transmucosal supply when fused to protein-based biologics. Sci. Transl. Med. 12, eabb0580 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Yokota, S. & Fahimi, H. D. Immunocytochemical localization of albumin within the secretory equipment of rat liver parenchymal cells. Proc. Natl Acad. Sci. USA 78, 4970–4974 (1981).

    Article 
    CAS 

    Google Scholar
     

  • Shroyer, Ok. R. & Nakane, P. Ok. Immunohistochemical localization of albumin and in situ hybridization of albumin mRNA. Cell Biochem. Funct. 5, 195–210 (1987).

    Article 
    CAS 

    Google Scholar
     

  • Pelletier, L., Jokitalo, E. & Warren, G. The impact of Golgi depletion on exocytic transport. Nat. Cell Biol. 2, 840–846 (2000).

    Article 
    CAS 

    Google Scholar
     

  • De Matteis, M. A. & Luini, A. Exiting the Golgi complicated. Nat. Rev. Mol. Cell Biol. 9, 273–284 (2008).

    Article 

    Google Scholar
     

  • Jiang, B. et al. A pure drug entry channel within the ferritin nanocage. Nano At present 35, 100948 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Huang, X. et al. Protein nanocages that penetrate airway mucus and tumor tissue. Proc. Natl Acad. Sci. USA 114, E6595–E6602 (2017).

    Article 
    CAS 

    Google Scholar
     

  • Liu, Q. et al. Modular meeting of tumor-penetrating and oligomeric nanozyme based mostly on intrinsically self-assembling protein nanocages. Adv. Mater. 33, e2103128 (2021).

    Article 

    Google Scholar
     

  • Ronneberger, O., Fischer, P. & Brox, T. U-Web: convolutional networks for biomedical picture segmentation. Med. Picture Comput. Comput. Help. Interv. 9351, 234–241 (2015).


    Google Scholar
     

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