Melero, I., Castanon, E., Alvarez, M., Champiat, S. & Marabelle, A. Intratumoural administration and tumour tissue concentrating on of most cancers immunotherapies. Nat. Rev. Clin. Oncol. 18, 558–576 (2021).
Lyu, L., Feng, Y., Chen, X. & Hu, Y. The worldwide chimeric antigen receptor T (CAR-T) cell remedy patent panorama. Nat. Biotechnol. 38, 1387–1394 (2020).
Nagarsheth, N. B. et al. TCR-engineered T cells concentrating on E7 for sufferers with metastatic HPV-associated epithelial cancers. Nat. Med. 27, 419–425 (2021).
Gong, N., Sheppard, N. C., Billingsley, M. M., June, C. H. & Mitchell, M. J. Nanomaterials for T-cell most cancers immunotherapy. Nat. Nanotechnol. 16, 25–36 (2021).
Morotti, M. et al. Guarantees and challenges of adoptive T-cell therapies for stable tumours. Brit. J. Most cancers 124, 1759–1776 (2021).
Galluzzi, L., Chan, T. A., Kroemer, G., Wolchok, J. D. & López-Soto, A. The hallmarks of profitable anticancer immunotherapy. Sci. Transl. Med. 10, eaat7807 (2018).
Levi, J. et al. Imaging of activated T cells as an early predictor of immune response to anti-PD-1 remedy. Most cancers Res. 79, 3455–3465 (2019).
Shi, C., Zhou, Z., Lin, H. & Gao, J. Imaging past seeing: early prognosis of most cancers remedy. Small Strategies 5, 2001025 (2021).
Nishino, M., Hatabu, H. & Hodi, F. S. Imaging of most cancers immunotherapy: present approaches and future instructions. Radiology 290, 9–22 (2018).
Scheper, W. et al. Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nat. Med. 25, 89–94 (2019).
Galon, J. et al. Kind, density, and placement of immune cells inside human colorectal tumors predict medical consequence. Science 313, 1960–1964 (2006).
Zhang, L. et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian most cancers. New Engl. J. Med. 348, 203–213 (2003).
Quail, D. F. & Joyce, J. A. Microenvironmental regulation of tumor development and metastasis. Nat. Med. 19, 1423–1437 (2013).
Jin, M.-Z. & Jin, W.-L. The up to date panorama of tumor microenvironment and drug repurposing. Sign Transduct. Goal Ther. 5, 166 (2020).
Gong, N. et al. Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for most cancers remedy. Nat. Nanotechnol. 14, 379–387 (2019).
Tang, L. et al. Concentrating on neutrophils for enhanced most cancers theranostics. Adv. Mater. 32, 2002739 (2020).
Zanganeh, S. et al. Iron oxide nanoparticles inhibit tumour progress by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat. Nanotechnol. 11, 986–994 (2016).
Gelderman, Ok. A., Hultqvist, M., Holmberg, J., Olofsson, P. & Holmdahl, R. T cell floor redox ranges decide T cell reactivity and arthritis susceptibility. Proc. Natl Acad. Sci. USA 103, 12831–12836 (2006).
Chakraborty, P. et al. Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells. J. Biol. Chem. 294, 9198–9212 (2019).
Hogg, P. J. Disulfide bonds as switches for protein operate. Developments Biochem. Sci. 28, 210–214 (2003).
Sahaf, B., Heydari, Ok., Herzenberg, L. A. & Herzenberg, L. A. Lymphocyte floor thiol ranges. Proc. Natl Acad. Sci. USA 100, 4001–4005 (2003).
Deng, H. et al. Focused scavenging of extracellular ROS relieves suppressive immunogenic cell loss of life. Nat. Commun. 11, 4951 (2020).
Gustafson, H. H., Holt-Casper, D., Grainger, D. W. & Ghandehari, H. Nanoparticle uptake: the phagocyte drawback. Nano At the moment 10, 487–510 (2015).
Sousa de Almeida, M. et al. Understanding nanoparticle endocytosis to enhance concentrating on methods in nanomedicine. Chem. Soc. Rev. 50, 5397–5434 (2021).
Schmid, D. et al. T cell-targeting nanoparticles focus supply of immunotherapy to enhance antitumor immunity. Nat. Commun. 8, 1747 (2017).
Arlauckas, S. P. et al. In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 remedy. Sci. Transl. Med. 9, eaal3604 (2017).
Ozsahin, M. et al. CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: a potential examine in 399 sufferers. Clin. Most cancers Res. 11, 7426–7433 (2005).
Wilkins, R. C., Kutzner, B. C., Truong, M. & McLean, J. R. N. The impact of the ratio of CD4+ to CD8+ T-cells on radiation-induced apoptosis in human lymphocyte subpopulations. Int. J. Radiat. Biol. 78, 681–688 (2002).
Weichselbaum, R. R., Liang, H., Deng, L. & Fu, Y. X. Radiotherapy and immunotherapy: a helpful liaison? Nat. Rev. Clin. Oncol. 14, 365–379 (2017).
Zhou, Z. et al. Early stratification of radiotherapy response by activatable irritation magnetic resonance imaging. Nat. Commun. 11, 3032 (2020).
Restifo, N. P., Dudley, M. E. & Rosenberg, S. A. Adoptive immunotherapy for most cancers: harnessing the T cell response. Nat. Rev. Immunol. 12, 269–281 (2012).
Hammerl, D., Rieder, D., Martens, J. W. M., Trajanoski, Z. & Debets, R. Adoptive T cell remedy: new avenues resulting in protected targets and highly effective allies. Developments Immunol. 39, 921–936 (2018).
Angelini, G. et al. Antigen-presenting dendritic cells present the lowering extracellular microenvironment required for T lymphocyte activation. Proc. Natl Acad. Sci. USA 99, 1491–1496 (2002).
Muri, J. & Kopf, M. Redox regulation of immunometabolism. Nat. Rev. Immunol. 21, 363–381 (2021).
Hildeman, D. A., Mitchell, T., Kappler, J. & Marrack, P. T cell apoptosis and reactive oxygen species. J. Clin. Make investments. 111, 575–581 (2003).
Kouakanou, L. et al. Vitamin C promotes the proliferation and effector features of human γδ T cells. Cell. Mol. Immunol. 17, 462–473 (2020).
Pelly, V. S. et al. Anti-inflammatory medicine transform the tumor immune atmosphere to boost immune checkpoint blockade efficacy. Most cancers Discov. 11, 2602–2619 (2021).
Tang, L. et al. Enhancing T cell remedy by way of TCR-signaling-responsive nanoparticle drug supply. Nat. Biotechnol. 36, 707–716 (2018).
Alam, I. S. et al. Imaging activated T cells predicts response to most cancers vaccines. J. Clin. Make investments. 128, 2569–2580 (2018).
Woodham, A. W. In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography. Nat. Strategies 17, 1025–1032 (2020).
Tavare, R. et al. An efficient immuno-PET imaging technique to observe CD8-dependent responses to immunotherapy. Most cancers Res. 76, 73–82 (2016).
Guo, Y. et al. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity. Nat. Immunol. 22, 746–756 (2021).
Scharping, N. E. et al. Mitochondrial stress induced by steady stimulation below hypoxia quickly drives T cell exhaustion. Nat. Immunol. 22, 205–215 (2021).
Kraaij, M. D. et al. Induction of regulatory T cells by macrophages relies on manufacturing of reactive oxygen species. Proc. Natl Acad. Sci. USA 107, 17686–17691 (2010).
Yan, Z., Garg, S. Ok., Kipnis, J. & Banerjee, R. Extracellular redox modulation by regulatory T cells. Nat. Chem. Biol. 5, 721–723 (2009).
Blakytny, R., Erkell, L. J. & Brunner, G. Inactivation of lively and latent remodeling progress issue beta by free thiols: potential redox regulation of organic motion. Int. J. Biochem. Cell Biol. 38, 1363–1373 (2006).
Laforge, M. et al. Tissue injury from neutrophil-induced oxidative stress in COVID-19. Nat. Rev. Immunol. 20, 515–516 (2020).
Furman, D. et al. Power irritation within the etiology of illness throughout the life span. Nat. Med. 25, 1822–1832 (2019).
Wright, H. L., Moots, R. J. & Edwards, S. W. The multifactorial position of neutrophils in rheumatoid arthritis. Nat. Rev. Rheumatol. 10, 593–601 (2014).
Csiszár, A. et al. Novel fusogenic liposomes for fluorescent cell labeling and membrane modification. Bioconjug. Chem. 21, 537–543 (2010).
